The move is to supply the Lions with depth at the position after placing wide receiver Ryan Broyles on Injured Reserve as well as wide receiver Titus Young, who had not been active the previous two games for non-injury related matters.
The Lions elevated Mike Thomas, who joined the team as the No. 4 receiver last month, to No. 2.
"Big opportunity," said Durham of being activated. "I've been working my butt off trying to get to this point. Unfortunately for Ryan, he was really coming into his own, bad stuff happens. I wish him nothing but the best but it also gives me a great opportunity ahead."
Durham, who is nicknamed "Bull" (most likely a dual reference to the 80s movie "Bull Durham" as well as his alma mater, the Georgia Bulldogs") said he was excited for his chance to get on the field and will do whatever it takes to make it work.
"I'll bring whatever they want me to bring," he said. "Whether it's special teams, offense, catch 10 balls, catch no balls, block for (wide receiver) Calvin (Johnson), block for the running backs. I don't really care, I just want to win."
Durham isn't alone in his excitement; it appeared Johnson may be looking forward to the Lions debut of the 6-foot-6 receiver.
After Durham had finished talking to the media, Johnson took a seat over at his locker – only a few away from Durham's – and shouted out to the second-year receiver.
"We are going to be some giants out there," said Johnson. "That's what I'm looking forward to."
Durham most likely fits in as an outside receiver, who can use his size to potentially be an easy target for Stafford when defenses role their coverage over to Johnson.
"Calvin's going to have all the coverage rotate to him so hopefully I can do my job," said Durham.
The 24-year-old receiver was a fourth-round draft pick of the Seattle Seahawks in 2011 but did have a pre-draft visit with the Lions.
He was part of the same signing class as quarterback Matthew Stafford, who he also roomed with for a while.
Durham's relationship with Stafford may help his transition on the field.
"It actually helps out quite a bit," said Durham. "If I might be confused on something he can actually give me a term from Georgia that helps me out… there's a lot of plays we've had in college that he's put in here."
Durham is currently living with Stafford, so his activation has brought him full circle.
From college roommates and teammates to professional roommates and teammates, Durham and Stafford could potentially make for an interesting combination as the season winds down.