Alabama turned the ball over 29 times in the loss, with the Lady Tigers recording 10 blocks on the afternoon.
"Obviously LSU is a very talented team and when they came into the game and started making outside shots it was nearly impossible to execute our scouting report," Alabama coach Stephany Smith said. "We just tried to focus on getting better each possession."
Alabama out rebounded LSU 37-35, with freshman Tamara Williams leading the Tide with seven rebounds. Senior Navonda Moore led Alabama with eight points, and freshman Nikki Davis had five. Alabama was 9-of-10 from the free throw line.
LSU (24-6, 10-4 SEC) was led by Sylvia Fowles, who had 12 points, 14 rebounds and two blocks in 17 minutes.
With Auburn's win over Ole Miss Sunday, Alabama (10-19, 0-14 SEC) will face the Rebels as the 12-seed in Thursday's opening round of the SEC Tournament at the Gwinnett Center in Duluth, Georgia. Ole Miss (20-8, 9-4 SEC) will be the 5-seed. The game is set for a 7 p.m. EST start.