Quigley lost his fifth straight decision and got no run support in a 7-3 loss to the Gators at McKethan Stadium in Gainesville.
The win clinches the series for the Gators, who are now two games ahead of the Crimson Tide in the SEC standings.
Alabama (26-22, 10-13 SEC) has scored 10 total runs during Quigley's personal five-game losing streak, including a total of four runs in losses to No. 1 Vanderbilt (L, 3-0), Georgia (L, 4-1), No. 4 South Carolina (L, 4-1) and Florida (L, 9-3).
Florida (25-23, 12-11 SEC) hit three home runs to clinch its fourth series win over Alabama in the last five years. First baseman Austin Pride, left fielder Jonathan Pigott and third baseman Jon Townsend all homered in the Gators win on Saturday.
Quigley (4-5), who has not won since beating Tennessee in the 2007 SEC opener back on March 16, gave up five runs and seven hits in 4 2/3 innings with two walks and three strikeouts. He also hit two batters, uncorked two wild pitches and added one balk.
UF junior right-hander Bryan Augenstein (5-5) baffled Alabama hitters through eight innings to even his season record on the mound. Augenstein, who entered the game with 6.35 ERA, held the Tide to two runs and five hits with one walk and 10 strikeouts.
Florida shortstop Cole Figueroa went 3-for-4 with one walk and scored three runs to pace the Gators 12-hit attack. Third baseman Jon Townsend added a season-high four RBI in the win, including a two-run home run and a pair of sacrifice flies.
Sophomore catcher Kyle Moore had a career-high three hits in the loss for the Crimson Tide. Alabama and Florida combined to hit three solo home runs in the second inning as the Gators took a 2-1 lead after two innings.
Junior first baseman Matt Bentley slammed his ninth home run of the season inside the right field foul pole to give the Crimson Tide a 1-0 lead.
Florida answered with two solo home runs in the bottom of the inning by Pride and Pigott to take a 2-1 lead. Pride's home run was his ninth of the season, while Pigott's was the first home run of his Gator career.
The Gators extended the lead to 4-1 in the bottom of the third inning on Townsend's two-run home run. Cole Figueroa drew a one-out walk and scored on Townsend's two-out, two strike home run into the left field bleachers.
Townsend added his third RBI of the game with a sacrifice fly in the fifth inning to give the Gators a 5-1 lead.
Florida tacked on two more runs against reliever Casey Kebodeuax when Brain LeClerc capped an 11-pitch at-bat with a two-run double off the left field wall to make it a 7-1 game.
Alabama loaded the bases with no outs in the eighth inning, but managed only one run on sophomore designated hitter Alex Avila's sacrifice fly to score Kyle Moore and make it a 7-2 game.
Florida added two more runs in the eighth inning after a 48-minute rain delay to make it 9-2. Alabama added unearned run in the ninth off Patrick Keating to make the final 9-3.
Alabama and Florida will wrap up this three-game SEC series on Sunday, May 6 at 12:06 p.m. (CDT) and the game will be televised by Sun Sports (DirecTV Channel 632) and SportSouth (DirecTV Channel 631).
*The game was delayed for 49 minutes due to rain and lightning in the bottom of the eighth inning.
*Alabama and Florida combined for four home runs on Saturday and the Gators have out-homered the Crimson Tide 5-1 in the series.
*Florida clinched the series with a 7-2 win on Saturday at McKethan Stadium. The Gators have won four of the last five series with the Crimson Tide. Alabama has lost its last three series in Gainesville and has not won here since 1999. Junior first baseman Matt Bentley (Hazel Green) hit his ninth home run of the season on Saturday and second only to Alex Avila's team-leading 11 home runs. Bentley has four home runs in his last seven SEC games.
*Sophomore left-hander Miers Quigley (Roswell, Ga.) had two pickoffs on Saturday, including one in each of the first two innings. He picked off UF shortstop Cole Figueroa at second base in the first inning and picked off UF catcher Cody Neer at first base in the second inning. For the season, Alabama has recorded an SEC-leading 22 pickoffs.
*Sophomore RHP Casey Kebodeaux (Mandeville, La.) stranded three inherited runners in the fifth inning on Saturday and has stranded all four inherited runners in the series. For the season, he has stranded five of six inherited runners. *Senior RHP Patrick Kelly (Dothan) also stranded one inherited runner in the sixth inning, giving the Tide bullpen four inherited runners stranded in the game.
*Dating back to April 7, Alabama relievers have stranded 36 of the last 44 inherited runners. From April 7-21, Alabama stranded 16 consecutive inherited runners. In the last five SEC games, the Tide bullpen has stranded 10 of its last 13 inherited runners.
*Sophomore catcher Kyle Moore (Wetumpka) had a career high three hits with a 3-for-4 day and recorded his first career multi-hit SEC game.