Now, Grandon is hoping that his final game at USC will end in a different manner.
"USC is USC," Grandon said. "Everybody wants to beat USC just to have that under their belt. This is going to be my last year to go to the Coliseum and get a win.
"I have been there once before when we lost, so it would be good to go into USC and get a win."
Grandon's job is a bit more difficult with the change in head coaches and possibly the offense.
"I feel like the coach will have a little bit of wrinkles in the offense, but for the most part they are going to run the same stuff they usually run," he said.
As of now, it looks like the Trojans will not have Marqise Lee. Grandon, however, does not believe that means USC is short on talent.
"They have a lot of good athletes and their quarterback can get the ball to his receivers and they have a good run game," Grandon said. "They are a good team all around.
"They still have weapons on the perimeter, but he is big threat. Their other receivers are capable of doing what he can do also though."
Grandon is familiar with what the Trojans are going through with the coaching change and believes there will be an increase in motivation.
"Coming from experience I know this is probably the time the guys get together and say ‘Hey it's just us now' and they have to play for each other," Grandon said. "I feel they are going to come out fired up and playing together as a team."
In order to counter that attitude, the Wildcats have to keep the USC offense in check.
"You just have to make sure you eliminate big plays," he said. "They are going to make some plays, but you have to make sure you move on to the next play and win that one."
Arizona is hoping that it does not drop its second Pac-12 game and knows that there is pressure to not do so.
"We know this is a big game," Grandon said. "This is a Pac-12 game and they are in the South, so we know we need to win this game to get our confidence back and make sure we are going in the right direction in the conference."