The Wildcats will win handily and the only way Colorado could keep the game close is if the Arizona defense is deeply hurt by the absence of Tra'Mayne Bondurant. Carey should run for 200-plus yards unless the Buffs fall behind by multiple touchdowns early.
Arizona 42, Colorado 21
Scott Coleman: This is an improved Colorado team from the one Arizona blew out last year. That being said, this game really shouldn't be close.
Colorado's defense ranks 110th in the nation in points allowed, and the fewest points it has given up to a Pac-12 team this season is 44.
Opponents are rushing for just under five yards per-carry against CU's front-seven, and the Buffs haven't played anyone as good as Ka'Deem Carey yet. Their pass defense -- even if it won't really be tested all that much on Saturday night -- isn't much better.
Look for Carey to have another monster day and for Denker to continue playing well as the Wildcats win with relative ease.
Arizona 37, Colorado 21
Michael Luke: I like the long-term prognosis for the Buffaloes. MacIntyre is a quality coach and Colorado is a place that any solid coach should be able to win big at.
Unfortunately, this current version of Colorado football stinks. CU is, however, better than last year's squad and at times capable offensively. As long as Paul Richardson doesn't go off, the Wildcats should be fine.
Arizona also has Ka'Deem Carey, who is clearly the best player in this game. Look for him to only rush for 250 yards this time en route to a convincing win.
Arizona 28, Colorado 10
Jason Scheer: I think this game is actually going to be closer than people think. Arizona may pull away in the fourth quarter, but Colorado is going to treat this as if it is its biggest game of the season.
Arizona will likely be aggressive defensively and try to take away the run as much as possible. Make Sefo Liufau throw as much as possible is not a good thing for Colorado and the Wildcats tend to do well with the type of routes that the Buffs run.
I think Carey goes for 200 yards and two touchdowns, but the defense will be the real story as it puts together its most complete game of the season.
Arizona 35, Colorado 21