Cody James Martin: There's hasn't been a game I have been more confident about all season than this one. Arizona is reeling and from the looks of the game last week has given up a lot of will to fight and win. Things might be different, but I'm not counting on it.
Anu Solomon hasn't been the same since his concussion and with several key linemen out, it's hard to see Arizona scoring much. The defense is in no better shape than it was a week ago and I expect USC to put up some big numbers early en route to the win.
USC 45, Arizona 10
Michael Luke: There's no way this Arizona defense is going to be able to stop USC's offense. Not only are the Trojans running the ball well, but the passing game is clicking as well.
Arizona used to be able to rely on its offense in games like this, but even that side of the ball is struggling. Expect Adoree Jackson to have his typical big game and the Trojans to run away with it.
USC 42, Arizona 13
Jason Scheer: USC and Arizona have played some close football games as of late, but that won't be the case here. The bigger story is how Arizona reacts a loss at Washington that sure looked like a team and coach that had given up.
The Wildcats have to prove that they are still focused on the season, but even a focused Arizona team is going to have difficulty stopping USC's trio of running backs.
USC 49, Arizona 17