Two late threes in the final 10 seconds cut the lead to single digits.
The game was very close until the Wildcats rattled off a 33-11 run to pull away from the Bears.
The Cats shot 60% from the field and a stellar 45% from the field. At one point in the first half the Wildcats made three pointers on three consecutive possessions.
Four Wildcats finished in double figures and Mustafa Shakur flirted with a a double double.
The senior point guard had eight points, nine rebounds and nine assists.
Marcus Williams led the Wildcats with 21 points, making all eight of his field goal attempts. Ironically enough, the sophomore struggled from the foul line, making just 4-7 from the charity stripe.
Five Cal players scored in double figures, led by Ryan Anderson's 16 points.
Cal went on a 19-6 run to end the game, getting a pair off threes in the final seven seconds.
Arizona is riding a 10-game win streak after losing the season opener in Virginia.