He knows that the Crimson Tide's 52-7 win extended the Rebels' SEC conference game losing streak to nine straight games – making current Ole Miss and former Arkansas coach Houston Nutt the first Rebels' coach that has ever happened to since the league's beginning in 1933.
Petrino is also well aware that Alabama not only beat up the Rebels (2-4, 0-3) on the scoreboard, but put two of their starting defensive players out for the season.
Still the No. 10 Razorbacks (5-1, 1-1) better come prepared to Oxford for the 11:21 a.m. game on Saturday according to the Arkansas head coach.
"We know we'll get their best shot," Petrino said. "They've got good football players and they're well coached.
"…We have to go down there and play well," Petrino added. "Alabama has done that to everybody."
"He's going to come out and get some work today," Petrino said. "Barring a setback, I think he will be ready for the game."
But senior defensive end Tenarius Wright – who was initially thought to be out four to six week – is still not near ready to play according to Petrino.
"He's a ways away," Petrino said of the young man who has now been out a month. "He's been working really hard on getting his legs back and running, and doing some of that, but's he's not close to playing yet."
While it is clear there are still some Arkansas fans that desperately want to beat the former Razorback coach, linebacker Jerry Franklin said the team's approach is no different than any other week.
"Aw, it kinda never was an emotional charge for me," Franklin said. " It's a game on the schedule playing against another team. A lot of the guys on the team - we don't look at is an emotional game but as just playing another team."
The Razorbacks had their open date last weekend after hammering Auburn 38-14 the Saturday before.
Petrino was happy with what his team got accomplished last week.
"I really felt like last week practicing was as fast and as sharp as we have practiced," Petrino said.
Arkansas practiced on Tuesday, Wednesday and Thursday before taking the weekend off.
"I thought we did a good job in the bye week," Petrino said. "I was happy with the way our players practiced. We got a lot accomplished. We spent the time kind of split up between preparing for Ole Miss and working hard on ourselves, on our own technique and fundamentals, and then practicing our young guys.
"So it was a good week and now we need to turn the clock and get ready for the game this Saturday and get back to our normal week of preparation, which I'm looking forward to," Petrino added. "We're going on the road and playing another SEC game."
Arkansas starting quarterback Tyler Wilson, who has absorbed some big hits through the season's first half, said the off Saturday couldn't have come at a better time.
"It was good to kind of recover and get your body right and it's good for everybody," Wilson said. "No matter if you are out there getting hit or you are a scout team guy. You get banged up through the course of a season and we are halfway through so it was perfect, perfect timing for a bye week for us to get recouped, get in the cold tubs and have a good weekend to kind of get away and relax and come back and tee it up again."
Wilson made it clear that his team respected every SEC foe regardless of how Ole Miss got beat up last weekend.
"It's an SEC-caliber team," Wilson said. "They're going to be good. They're well coached. It's going to be a battle. It is every week. Obviously, you're going to have respect for them no matter what happened on Saturday."
The Razorbacks were No. 9 in the first BCS poll, which was released on Sunday night.
"The way I look at that is all our players know that, all our coaches know it," Petrino said. "It needs to be a motivating factor to come to practice each day and get better. It's something that didn't just happen. Our players put a lot of hard work and a lot of dedication into it. We've competed extremely hard, we've stuck together when we could have fell apart, so there's a lot of positives in it, but what it needs to be for us now is to really understand that if we're tough enough mentally to focus one practice at a time, work on getting better one practice at a time, then we've got a chance to keep winning."
Wilson noted that while ninth was the highest that Arkansas has been in the BCS poll in its short history, it was not where the Razorbacks wanted to end up.
"It's kind of an honor to say this is the first time in school history that we've been ranked at that point this early," Wilson said. "Obviously, we have some work ahead of us and we've got a lot of goals that are much higher than that. We're not going to get too caught up in it. We're going to come out and try to achieve the goals that are still ahead."
Arkansas was 4-2 this time last season after losses to Alabama and Auburn.
The Razorback would win the next six games - something they would like to do this season as well.
"I think the way you do it is you work on one game at a time and that's all you focus on," Petrino said. "You work hard on your preparation. You work hard on how you practice."
If Arkansas runs the table against this season, it could be because of coming together when down 35-17 to Texas A&M in week 5.
"Really I was thinking about halftime of the (Texas) A&M game when I made that statement," Petrino said. "That was a point where it was really important that everyone rallied around each other and no finger pointing, look inside yourself and understand how can I come out in the second half and help us win the game. I really felt like our players did that and grew."