Missouri overcame a sluggish start and blitzed the Razorbacks with a 93-63 win in front of 15,061 fans in Anderson's first game back since leaving for Arkansas two years ago.
"Congratulations to Missouri," Anderson said. "It was senior night tonight so you expect emotions to be running sky high. I think those seniors set the stage for them."
Arkansas sophomore guard BJ Young, a Missouri native from St. Louis, had a game-high 27 points for the Razorbacks (18-12, 9-8).
"I think they had a lot of momentum going their way and they kept the momentum for a while," Young said. "They killed us on the glass. They got a lot more physical than we did. I think their seniors stepped up for them on their senior night. Their crowd was really rocking and I think we have gotten overwhelmed or something of that nature."
Four players scored in double-figures for the Tigers, led by senior Laurence Bowers' 24 points.
Bowers, one of two remaining players who played for Anderson along with junior point guard Phil Pressey, were among three Missouri seniors playing their final game at home.
Jabari Brown, who scored a game-high 25 points in the loss at Arkansas, added 20 points as the Tigers improved to 17-0 at Mizzou Arena this season.
"Bowers was fantastic, and Phil, he's going to run the show - that's what he does - he's a great point guard," Anderson said. "Brown shot the ball well too. They had a lot of things going in their direction so you have to give them a lot of credit. It was a great atmosphere. Congratulations to them."
The Tigers (22-8, 11-6 SEC) avenged a 73-71 loss to the Razorbacks in Fayetteville last month by hitting 58 percent of their field goal attempts. Missouri led by as many as 34 points.
"Obviously it was a really good game for us," Missouri head coach Frank Haith said. "I thought our guys played really hard. Defensively, we were really good in the first half. I thought our offensive execution was outstanding. Once again, we had 40 plus points in the paint. All in all, it was a good performance."
It was certainly an emotional game with it being the seniors' last game and return of Anderson in a contest that started late because of a shot clock malfunction.
"It was just an intense game in terms of we needed to get a conference win," Haith said. "It's March, so everybody's battling this time of year. I did talk to our team about dialing down the emotion. Obviously, you're not in your normal routine. The start of the game gets pushed back because of the shot clock deal. Senior night is always emotional. I talked to our guys about how to temper that. The first five minutes, you're not going to knock anybody out of the game. I thought our guys handled it well.
The diminutive Haith didn't follow his own suggestion and appeared to charge after Anderson during one stretch and had to be held back by his assistants as the Arkansas coach smiled at the uproar.
"I thought it was a miscommunication," Haith said. "I'm emotional and I was emotional for my team. I was encouraging my team and I think he thought I was saying something else, but I was only talking to my team."
Anderson was asked about his return to Mizzou Arena.
"It was just another game for me," Anderson said. "The only thing that was emotional for me was seeing the kids I brought here. You go back to when we came here, and this program, and what is taking place. There is passion about Tiger basketball and that is good to see. I think Frank has done an excellent job of getting this team to play excellent basketball.
"I thought it was a great atmosphere tonight," Anderson added. "There were two teams who were trying to really finish up the season on a nice run. They are playing some good basketball. It was good to see some old friends."
Arkansas forced five turnovers before the first media timeout to stake a 7-5 lead, but folded from there.
Missouri used a 9-0 run a little more than midway through the first half to build a 15-point cushion and scored the period's final 13 points to take a 48-22 lead into halftime.
The Razorbacks (18-12, 9-8) made just 1 of 15 attempts from 3-point range in the first half.
"It's certainly frustrating," Arkansas junior guard Kikko Haydar said. "Our game plan coming in was not too many threes to be honest with you. We did a bad job of following through on the game plan so we'll have to go back to work, see what we did wrong, and get ready for A&M."
The 30-point loss was Arkansas' most lopsided ever to Missouri in a series that dates to 1950. The Razorbacks fell to 1-11 away from home this season.
"We knew there was going to be a lot of emotion," Haydar said. This was the game I'm sure they've circled all year and they've been waiting for, especially the fans. I gotta hand it to them. They played well and they got what they came for."
Arkansas will conclude the regular season with a 1 p.m. game against Texas A&M on Saturday at Bud Walton Arena.