Wise broke open a scoreless game with a fourth-inning liner over the wall in left as the Hogs cruised to an 8-0 lead. Ryne Stanek (4-2) pitched 6 2/3 shutout innings. LSU plated three in the ninth before Michael Gunn got the final three outs.
The No. 2 Tigers (33-3, 12-2) lost for the first time since March 17, at Mississippi State. The No. 10 Hogs (25-11, 9-5) will have a chance to win their fourth straight SEC series at 1:05 p.m. Sunday.
"It was about the same as last night," Arkansas coach Dave Van Horn said. "They got a three-run homer, went up 5-0. We did the same tonight.
"Overall, as a team we played extremely well. It was a great job at the plate and Ryne pitched an outstanding game."
Stanek has been superb of late. He has not allowed a run in his last 14 2/3 innings. He lowered his ERA in SEC games to 0.56.
Dominic Ficociello led a 12-hit UA attack with three hits. He reached base four times and scored twice.
But it was Wise that did the damage. Brian Anderson led off the fourth with a single and Ficociello walked before Wise took a Ryan Eades fast ball to the back of the UA bullpen.
It was the first home run allowed by Eades, the LSU ace with seven victories in his first eight starts. Eades (7-1) had allowed only five extra base hits in 55 innings.
LSU coach Paul Maniera went to the mound to talk to Eades before the Wise homer. Van Horn and Wise both thought the visit was to go over the possibility of a squeeze bunt.
"We talked about that," Wise said. "I believe they thought that possibility. So I was looking for a fast ball. He'd beat me with the fast ball earlier in the game."
Wise lifted a fly to center for an RBI sacrifice fly in the fifth. It was a career best four RBI on the night.
The Hogs broke it open with three in the seventh. Bret McAfee had a bases loaded walk. Jacob Mahan drove home two with a high chopper that went over the third baseman.
Stanek allowed only four hits in a 103-pitch outing.
"Ryne had command of all four pitches," Wise said. "I thought it was one of his better performances."
Stanek did like his command, but didn't think his "stuff was as good as it has been lately. I thought the couple of times they did hit it hard, it was something at our guys."
The Hogs shuffled their lineup and committed only one error, a bad throw by Mahan at third. McAfee played short, Anderson went to left and Matt Vinson slid over to center.
Joe Serrano remained on the sick list, but Van Horn is hopeful the team's best hitter in SEC play will return Sunday when the Hogs send Randall Fant to the mound in hopes of a series win.
"Serrano has had a tough week," Van Horn said. "I think he'll play tomorrow. We were going to play McAfee last night, but he was sick. We've had several throwing up this week but maybe we are about over that."
The only disappointment came in the ninth when reliever Landon Simpson failed to retire any of the four batters he faced. Jalen Beeks had recorded four straight outs in relief of Stanek.
"We were trying to get some guys some work in the ninth," Van Horn said. "Coach Manieri pulled some guys, too.
"I thought our offense was good tonight. Last night, (Aaron) Nola didn't allow us to get the leadoff man on. Tonight we did and that allowed us to make some decisions."
The Hogs put the leadoff batter on base six of the first seven innings. Seven of nine UA hitters had hits.
"We were trying to be aggressive," Van Horn said. "I think we just did a good job tonight. We were swinging with confidence and it was contagious. I think the dugout was feeling good."
Manieri said it was just not LSU's night.
"You could almost tell right from the start," he said. "I thought we hit several balls really hard off Stanek early in the game. In the third inning all three outs were hit as hard as our three batters could hit the ball.
"Ross crushed one into left center field that without the wind would have probably been a home run. McMullen smokes one into center field and Laird smokes one right at left-fielder and you say to yourself that you're hitting this guy, we're getting to him, and he's legit, he's good, he's going to be a first-round pick throwing 95 mph."
"It just caught up to Ryan (Eades). He walked two guys to lead off innings and gave up hits in two other innings to the lead off batter. Four times out of five you let the lead off hitter get on base. Eventually the breaks of baseball are going to catch up with you.
"Just one of those night. Ryan has had such a great year and has been perfect really, and today he just wasn't his typical self and that happens in this sport. Tip your hat to Arkansas, they have great players and you know they're eventually going to bust out."