Ole Miss tagged Zach Jackson for six runs and hung on late to beat Arkansas 14-9 and clinch the series Saturday night.
It is the No. 21 Razorbacks' third SEC series loss in four weekends.
Making his first start of the season, Jackson tied a career high with eight strikeouts, but allowed six runs - five earned - in five innings of work.
The No. 15 Rebels (24-7, 5-6 SEC) didn't waste any time, loading the bases with one out before a two-run single by Henri Lartigue in the first inning, marking the 10th time in 11 SEC games Arkansas' opponent scored first.
They doubled their lead in the next frame thanks to a Connor Cloyd RBI double and Ryan Olenek RBI groundout.
Jackson settled down after that, retiring 10 of the next 12 batters he faced, but it didn't last. He hit Michael Fitzsimmons with a pitch to lead off the sixth and Will Golsan singled his 100th and final pitch of the night through the right side.
They eventually scored, sparking a three-inning stretch in which the Rebels scored 10 runs to pull away from the Razorbacks (20-11, 4-7).
Arkansas scored four runs in the top of the eighth after the game was delayed by a cat running onto the field. The rally was aided by a dropped fly ball immediately following the stoppage and included RBI singles by Michael Bernal, Tucker Pennell and Grant Koch. Rick Nomura also had a sacrifice fly.
It was a short-lived comeback attempt, as Ole Miss responded with a six-run home half of the inning.
The runs proved to be important because Arkansas scored four in its final at bat.
Luke Bonfield hit a solo home run, his sixth of the season, in the fourth inning.
The Razorbacks will try to avoid its second sweep of the season Sunday at noon. The game will be televised on the SEC Network.