Auburn got the ball first in overtime and drove the ball in for the touchdown from the 25 in five plays. Auburn clinched the victory on Louisiana Tech's second offensive play of overtime when Dontarrious Thomas intercepted McCown's pass.
The Tigers led 34-20 at the end of the third quarter, but the Bulldogs scored three touchdowns in the final period to tie the game.
Both teams had more than 500 yards total offense in a game that featured eight touchdown passes and saw both quarterbacks pass for almost 400 yards. McCown also threw five interceptions and Cobb was intercepted four times.
Louisiana Tech's Joe Smith was the game's leading rusher with 129 yards including a 27-yard touchdown run in the fourth quarter. Auburn freshman Carnell Williams rushed for 78 yards, including an 11-yard scoring run that gave the Tigers a 41-27 lead with a little over five minutes to play in the game.
After a slow start in which he threw two interceptions in the first nine minutes of the game, Cobb caught fire and threw four scoring passes before intermission.
Trailing 3-0, Auburn scored on the final play of the first quarter on a 16-yard pass from Cobb to Silas Daniels.
It took less than 30 seconds for the Tigers to score again as DeMarco McNeil intercepted a McNown pass on the Bulldogs first play from scrimmage after the kickoff. On the next play, Auburn's Lorenzo Diamond scored on a 22-yard screen pass from Cobb.
Cobb also threw second quarter touchdown passes of 32 yards to Deandre Green and 59 yards to Tim Carter.
Auburn coach Tommy Tuberville lived up to his gambling reputation with Auburn holding a 14-10 lead and facing fourth down and one from their own 22 in the second quarter. Tuberville went for the first down and the Tigers converted on a 3-yard run by Ronnie Brown, part of an 87-yard scoring drive.
Before missing the last second kick at the end of regulation, Duval had hit game winning field goals in Auburn's last three games, including a 44-yarder with 10 seconds left to give the Tigers a 23-20 upset win over then-No. 1 Florida last week.