Trailing 24-21, Manning drove Mississippi 35 yards on three plays, hitting Zeigler with a 17-yard touchdown pass to make it 28-24.
Ole Miss recovered Devery Henderson's fumble with 5 minutes and five seconds remaining in the game. Seven plays later Manning found Zeigler again, hitting him for a 4-yard touchdown that made it 35-24 Mississippi.
Manning, who completed 28 of 44 passes for 249 yards and three touchdowns, tied his father, Archie Manning for the school record of eight consecutive games with a touchdown pass. Manning, forced to scramble all night, also threw his second interception of the season.
Facing the top pass defense in the nation, LSU (4-3, 2-3) relied on its running game, gaining 188 yards rushing, led by Domanick Davis with 99.
LSU's Rohan Davey completed 9 of 23 passes for 183 yards. He was intercepted once and sacked twice.
Matt Grier picked off Davey's pass in the first quarter to set up the Rebels' first touchdown. Ole Miss needed just seven plays to drive 36 yards, with Toward Sanford carrying it the final yard to make it 7-0.
On their next possession, LSU alternated handing the ball to Davis and LaBrandon Toefield, who led the SEC in scoring going into the game but did not start because of an ankle injury. LSU drove to the Ole Miss 4 before attempting its first pass.
On third down, L.P. Spence sacked Davey for a 5-yard loss and the Tigers settled for a 26-yard field goal to make it 7-3.
Toefield rushed seven times for 40 yards before reinjuring the ankle. He did not return in the second half.
In the second quarter, a reverse sent Michael Clayton scampering around the right side where he got a key block from Davey en route to a 29-yard scoring run that stretched LSU's lead to 10-7.
Manning, under heavy pressure, was forced to scramble frequently. After four straight incompletions, a 15-yard pass- interference call against the Tigers kept the drive alive. Then on fourth-and-10 on the Tigers 30, Manning managed to loft a 27-yard pass to Bill Flowers. Two plays later, Joe Gunn leaped in from a yard out to put Ole Miss up 14-10.
With 37 seconds remaining in the half, Rob Robertson blocked the LSU punt, giving Ole Miss first down on the Tigers 23. Three plays later, Manning hit Omar Rayford with a 4-yard touchdown pass that made it 21-10.
In the third quarter, Davis returned a punt 71 yards to cut Mississippi's lead to 21-17. Davey hit Claton for a 39-yard touchdown that made it 24-21 LSU.