"This decision was difficult for me and my family," said Newton, whose Auburn team won the BCS National Championship on Monday night.
Newton celebrates at TD with Emory Blake and Ryan Pugh.
"After talking to Coach Chizik (head coach Gene Chizik) and Coach Malzahn (offensive coordinator and quarterback coach Gus Malzahn), I think it is best that I make that next step in my career and forgo my senior season and enter the NFL Draft.
"It was a very hard decision for me, especially after coming off the great season we had at Auburn," Newton added. "I'm blessed to have been around an excellent environment and have great teammates, coaches and support from the Auburn family."
Cam Newton played one season for the Tigers.
Newton rushed for an SEC record 1,473 yards for a quarterback and 20 touchdowns while passing for 2,854 yards and 30 scores in his one season with the Tigers.
"It's been a blessing for me to be a part of something so great," the 6-6, 250-pound quarterback said. "Any time you win games it's a big deal, but for this school to win a BCS National Championship, what a way to make people happy. Auburn is a special place that I can call home."
Newton is shown with the Heisman Trophy he won.
Newton set Auburn single season records for rushing touchdowns with 20, passing TDs with 30 and TD responsibility (51). His 4,327 total yards are an Auburn and SEC record for a single season.
"We appreciate Cameron's many contributions to Auburn and the outstanding leader that he was for our football team," Chizik said. "He had one of the greatest individual seasons ever by an Auburn player and was a key part of our championship run. Cam will always be a member of the Auburn family and we wish him the best in his future endeavors."
Newton was the SEC Offensive Player of the Year and won the Walter Camp, Maxwell and AP National Player of the Year Awards as well as the Davey O'Brien Award as the nation's top college quarterback.