Holsey suffered a knee injury in practice and did not make the trip to Texas A&M for Auburn's first-ever game in College Station.
Holsey, who made six starts at cornerback as a true freshman last season, moved to safety near the end of spring training this year and started the first six games there this season. He won praise for his performance from defensive coordinator Ellis Johnson and head coach Gus Malzahn.
The safety, who suffered a torn ACL, has 11 solo tackles with six assists and one interception this season. With the injury coming at the halfway point of the season he is not eligible for a medical hardship redshirt.
Holsey signed with Auburn out of Creekside High School in Fairburn, Ga., where he was a heavily recruited prospect.