A pair of newcomers also stepped up with solid efforts. Freshman Natasha Brackett scored 16 points and added seven rebounds while junior Kerdu Arbet scored a career-high 10 points.
Auburn improved its record to 14-4 overall and 2-3 in the SEC. MSU is now 12-6 overall and 3-2 in the conference.
"We played very well today," Auburn coach Joe Ciampi said. "These players did more than you could ever ask considering the recent injuries that have occurred. Carol seemed to get in the flow and once we noticed that, we went to her."
Smith hit 10-15 field goals. She was 3-3 on treys, and f-4 at the foul line and added two assists, three stills and had just two turnovers in 35 minutes of playing time.
Auburn led 36-32 at the break and then built a substantial lead thanks to a 10-2 run early in the second half.
All-SEC LaToya Thomas led the visitors with 19 points and 13 rebounds. Tan White scored 19 and added eight rebounds and seven assists.
Auburn hit 50.9 percent of its field goals and 18-24 free throws. AU enjoyed a plus 11 margin on the boards. The visitors were limited to 38.7 shooting.
Auburn will try to even its conference mark at 3-3 in a 7 p.m. game on Thursday at Alabama.