Freshman guard DeWanna Bonner led all scorers with 14 points. She added five rebounds for the Tigers, who improved to 2-1.
The Tigers got 13 points from sophomore forward Alexis Ogubie and 11 apiece from senior center Marita Payne and freshman point guard Whitney Boddie.
"It's good when you can spread the ball around," said Auburn coach Nell Fortner. "We don't just count on one person so that was good to see."
Auburn shot 43.9 percent vs. George Mason, which fell to 2-1 with the loss. Tacey Ann Holness led the Patriots with 13 points.
The Tigers led 32-19 at intermission and put the hammer down in the second half outscoring George Mason 45-17.
Coach Nell Fortner was able to clear the bench. In addition to 11 from Boddie in reserve, guard Joanna Clayden added nine points for the Tigers and center Keke Carrier added five points, five rebounds and four blocked shots. Aileen Rossouw added four points and seven rebounds off the bench.
George Mason coach Debbie Haneyhill said, "We're a young team. We're trying to find out exactly where we are and right now we have a long way to go. Auburn is very talented. Obviously their size was a big problem for us, but we'll see how we respond to this setback quickly tomorrow."
Auburn's Fortner said, "Well, you learn from every game. You just try to get better every game. That is our goal, just to play hard, give great effort and to do better every time--set better screens, keep them off the offensive boards better and things like that. We gave up 14 offensive rebounds and that's too many."
The Tigers won the overall rebounding battle 43-33 and hit 21-28 free throws to just 1-7 for George Mason, which was 5-21 on threes. Auburn made 61-5 three-pointers.