USC struggled with its shooting, too, making just 35.6 percent of its field goals. However, the visitors had seven fewer turnovers and fired up 59 field goals to just 42 for the Tigers.
Senior guard Nitasha Brown scored 13 points for the Tigers. Freshman guard DeWanna Bonner added 12 points and 11 rebounds.
The Tigers got 10 points and 10 rebounds from freshman center Keke Carrier and freshman forward Sherrell Hobbs added 11 points in a reserve role.
Senior Marita Payne moved into second place in SEC history in career blocked shots. She swatted away seven to move her total to 370. Payne added five rebounds, but did not score.
Auburn hit just 18-30 free throws while the visitors made 11-13 and 5-10 treys. Auburn hit 4-5 three-pointers.
South Carolina was led by guard Lea Fabbri who scored 13 points and added six rebounds.
"It was an ugly night," Auburn coach Nell Fortner said. "We did nothing good offensively. It just wasn't a good night for us."
"You would think we would have a chance going to the line 30 times," Fortner said. "We just couldn't get the second one in on the one-and-one."
South Carolina coach Susan Walvius said, "We have different people that step up for us every night. We played very sloppy tonight and you have to give Auburn credit. They are a great shot-blocking team.
"I don't think that either team is pleased with their performance tonight, but we will take the win. This is our fourth straight SEC win on the road and that is good."
The Gamecocks never trailed, but led just 25-22 at halftime. The Tigers kept in striking range most of the game, but the visitors managed to hit key baskets whenever Auburn would make a run.
Auburn will play its final home game on Sunday at 2 p.m. on Senior Day for Payne and Brown.