Arizona, which came into the day 10 points ahead of Auburn and 14 ahead of Georgia, slipped into third. The Bulldogs have 379 points, while the Tigers have 326 and the Wildcats have accumulated 315 points.
Auburn freshman Rachel Goh won the individual national championship in the 100 backstroke.
"It feels so amazing right now," Goh said. "I just wanted to go out there and do it for my Auburn team. I just went out there, gave it my all and it was great."
The Tigers also got a big lift from Corey Gerlach in the three-meter diving, finishing in third. In the 400 individual medley, Auburn had three of the top five finishers. Julie Stupp (second), Adrienne Binder (fourth) and Lauren Duerk (fifth) all scored big points.
Hayley Peirsol, who finished second in the 500 freestyle on Thursday, also finished second in the 1650 free on Friday. Binder hit the boards just behind her in finishing third.
"Certainly the 100 back, three-meter diving, 400 IM and 800 relay were highlights tonight," said Auburn head coach David Marsh.
Tawnie Bethune came in eighth in the 100 butterfly and Emily Kukors in third in the 200 free.
In the final event of the night, Jana Kolukanova, Emily Kukors, Jeri Moss and Binder came in third in the 800 free relay.
"We somewhat put that relay together at the last minute," Marsh said. "It was Adrienne's best split on an 800 free by a long shot. It was a great way to leave the pool tonight."
The Tigers strongest day on paper heading into the event would be on Saturday, and they'll certainly need a big effort to make ground on the 53-point deficit to the defending champs and home-standing Bulldogs on the final day.