Tipoff is set for 6 p.m. CST in Auburn's final contest before beginning Southeastern Conference play.
Lebo's Tigers, who are 10-4, feature five players scoring in double figures with a 15.0 average by junior forward Quan Prowell as the top number. Josh Dollard, a sophomore forward, is the top rebounder with 8.3 per contest.
Auburn leads the series 14-1 and has won the last 12 meetings with Southern Miss.
"They are a very physical and tough Southern Miss team that is off to a good start," Lebo says. "I've been down there before when I was at East Tennessee State and it is a tough place to play. We will see what we are made of down there. We have some more road games coming up so it will be a good test for our kids."
Auburn is coming into the contest off a 69-53 victory over Charleston Southern. Southern Miss won its last outing, 58-41, vs. visiting McNeese State.
Coach Larry Eustachy is relying on a youthful lineup with three freshmen starters and two sophomores. The group is outscoring opponents by 17.7 points per outing and out-rebounding opponents by a margin of 12.1.