Ole Miss built a 15-point halftime lead and kept a double figures lead most of the second half, but the Tigers managed to cut the gap to 70-66 on a three-point shot by Joanna Clayden with 1:40 to play.
However, Auburn couldn't make a shot the rest of the way and fell to 13-4 for the season while Ole Miss improved to 12-4.
The Tigers played without 6-7 center Keke Carrier, who is out indefinitely after suffering a stress fracture in her foot. In her absence true freshman Mimi Pickard made her college debut. The forward has been recovering from surgery for a knee injury she suffered her senior season at Carver High in Columbus, Ga. She played two minutes and didn't score or have a rebound.
DeWanna Bonner's early foul trouble caused a bit problem for the Tigers.
Auburn dug its hole in the first half by hitting just 9-28 field goals and turning the ball over 11 times while Ole Miss had just five turnovers and hit 14-34 field goals.
For the game the Tigers shot 41 percent, including 6-17 on threes, while the Lady Rebels made 44.1 percent of their shots, including 4-11 on threes.
Ole Miss outrebounded Auburn 41-36 and had two fewer turnovers.
Tamela McCovery led Auburn with 14 points and three assists. DeWanna Bonner, who got into early foul trouble and played just four minutes in the first half, scored a dozen points as did teammate Sherrell Hobbs, who added 11 rebounds.
Senior guard Armintie Price led the winners with 24 points. She hit just 8-24 field goals, but was 6-7 at the foul line while adding four points and two steals.
Auburn coach Nell Fortner said, "We made a nice run at them, but we couldn't make stops on the other end. Ashley Awkward hit some big shots. We couldn't seem to guard her for three times down the floor."
Awkward finished with 10 points and with eight coming in the second half.
For the Tigers freshman forward Jordan Greenleaf scored 10 points and added nine rebounds while Whitney Boddie chipped in with six points and seven assists.
Auburn returns to action with a 2 p.m. game on Sunday at Alabama.