It was by far Auburn's worst performance of the season as the Tigers dropped to 17-9 overall and 4-6 in the SEC. Vanderbilt improved its record to 21-4 in the SEC and 7-3 overall.
To lose by such a lopsided margin, a lot of things had to go wrong and that was the case at Memorial Gymnasium.
For starters, Vanderbilt made seven of its first nine shots as Auburn played seven minutes before scoring a basket. The Tigers trailed 39-16 at halftime.
Auburn was dominated on the boards with the home team taking a 40-22 edge in rebounds.
The Tigers shot the ball poorly, particularly in the first half when they made just 6-20 field goals. For the game Tigers hit just 33 percent of their 45 field goal attempts while Vandy made 58.6 percent of its 58 shots.
Vandy made 5-9 threes while Auburn hit just 2-8.
Auburn coach Nell Fortner said, "This was one of those days. We got off to a cold start and couldn't recover. This team doesn't quit, and I'm proud of the way we continued to play hard."
Vandy has now won 11 straight matchups with Auburn. VU star Carla Thomas led the winners with 15 points while Liz Sherwood and Ashlee Bridge scored 14 apiece.
For Auburn, DeWanna Bonner led the scoring with 12 points while Sherell Hobbs added 10 points. Bonner hit 4-7 field goals and Hobbs made 3-5 field goals.
Each team had 15 turnovers, but Auburn's earlier miscues help the home team build the big early lead.