Booker hit 5-7 treys on the way to scoring 27 points. The Tigers managed to hit just one three-pointer in 10 tries.
Sherrell Hobs led the Tigers with 16 points and six rebounds. The sophomore made 8-11 shots and added a pair of steals.
Whitney Boddie scored 13 points and dished out four assists with just one turnover for the Tigers. Tamela McCorvey added 12 points for Auburn.
Normally Auburn's top scorer, DeWanna Bonner struggled. She was 0-8 from the field and finished the game with five rebounds and no points.
Auburn took a six-point lead in the first half with 7:06 to play, but the home team rallied to take a 33-25 advantage into the locker room at halftime. South Carolina shot 57.7 percent in the final 20 minutes to ice the victory.
For the night the Tigers hit 41.9 percent of their field goals and 8-10 foul shots. USC made 44.3 percent of its shots and 11-14 free throws.
The rebounds and turnovers were close. USC enjoyed a 37-33 edge on the boards and had 14 turnovers, one less than Auburn.
Auburn coach Nell Fortner said, "We just couldn't contain Stacy Booker. She had a great night, and we didn't have answer for her."
As has been the case in other games this year, the Tigers didn't finish well. Trevesha Jackson, who tied the score at 61-61 with two free throws with 1:54 left, finished with nine points as did Jordan Greenleaf. However, the Tigers were shut out the rest of the way.