The Commodores hit 10-20 three-pointers while giving the Tigers a third straight loss. The Commodores improved to 21-7 overall and 10-3 in the conference.
Auburn, now 18-10 overall and 6-7 in the SEC, looked like a solid bet to earn an NCAA bid earlier this month, but that isn't likely going to happen unless there is a quick turnaround after losing three consecutive games.
"Whether we played man or zone, we couldn't guard the three," said Auburn coach Nell Fortner, whose team made just 3-14 three-point attempts.
Commenting on her team's shooting, Fortner said, "We just didn't have much dropping for us shooting 32 percent. I thought we had some good looks."
Auburn's DeWanna Bonner takes a shot vs. the Commodores.
Junior DeWanna Bonner led the Tigers with 19 points and 10 rebounds while junior guard Sherrell Hobbs added 18 points and five rebounds. The Tigers were led on the boards by freshman center Cassie Moore, who pulled in a career-high total of 12 rebounds.
Vandy, which shot 47.5 percent from the field, got 19 points apiece from Jessica Mooney and Merideth Marsh.
Auburn out-rebounded Vandy 38-37 and turned the ball over 13 times, two more than the visitors.
Auburn was 17-24 at the foul line 'bonner hitting 11-12. Vandy made 5-9 foul shots.
The Tigers return to action with a 2 p.m. Sunday home game vs. Arkansas to close the regular season. The SEC Tournament will start March 6th in Nashville.