The game will be played in Ford Field as part of an afternoon of football being dubbed the Collegiate Clash.
Wayne State and Hillsdale will meet at noon while the Chippewas and Eagles will do battle at 4:30 p.m.
Central Michigan is coming off an incredible come-from-behind 24-21 Mid-American Conference win over Western Michigan University on Saturday.
Down by a 21-7 margin with 3:14 to play in the game, the Chippewas scored twice to force overtime and then won it on a 25-yard field goal by walk-on freshman Ronald Budd.
"Good things happen when you never give up and keep trying to find a way to win," said CMU head coach Brian Kelly. "It didn't look good with three minutes to play but we've tried to instill in our players all season long that we have to fight until the end."
The win upped CMU's record to 3-5 for the season and 2-3 in MAC play. Eastern Michigan, a 41-20 loser at Bowling Green on Saturday, is now 3-5 overall and 3-2 in loop play.
Kelly is looking forward to playing at Ford Field.
"This is a great preview of the place where we'd like to end up one day in the Motor City Bowl," said Kelly. "Our players are excited, I'm excited.
"You have two new programs playing at a great venue. It should be a great football game.
"Eastern Michigan runs the spread offense and does an excellent job with it. Jeff (Genyk) has that football team believing in itself."
The Chippewas next go on the road to Buffalo on Nov. 13 before returning to Kelly/Shorts Stadium for the final game of the season on Nov. 20 against Ball State.
Central Michigan -- Brian Kelly (Assumption, 1983). Career record: 121-40-2 (13th year). CMU record: 3-5, first year.
Eastern Michigan -- Jeff Genyk (Bowling Green, 1982). Career record: 3-5. EMU record: same, first year.
CMU owns a 52-23-6 lead in the all-time series with the Eagles that began in 1902 with a 10-0 Chippewa win.
CMU has played EMU more than any other opponent -- 81.
The Chippewas have won three in a row while the Eagles' last win came at home in 2000 by a 31-15 margin.
Scouting Eastern Michigan
The Eagles had their two-game winning streak halted at Bowling Green, 41-20, on Saturday.
EMU has MAC wins over Buffalo (37-34), Ball State (31-24) and Western Michigan (35-31).
Eastern is fourth in total offense (434.6) and 12th in total defense (446.0) in the MAC. EMU is third in rushing (169.6), fourth in pass offense (265.0) and fifth in scoring (29.2).
QB Matt Bohnet has completed 161-of-303 passes for 2,093 yards and 16 TDs against just five interceptions. He's second in the MAC in total offense (314.1), fourth in passing (261.6) and seventh in pass efficiency (125.3).
WR Eric Deslauriers is second in the MAC in receiving (7.25 per game) with 58 grabs for 939 yards and nine TDs. His 117.4 yards an outing are also second.
TB Anthony Sherrell is seventh in rushing with 76.1 yards per game.
PK Andrew Wellock has connected on 14-of-15 field goals and leads the league with 1.75 field goals per outing. He's second in the MAC in scoring with 8.2 points per contest.
Chippewa Training Room
•Eric Tunney (defensive tackle), is out for the season with a leg injury.
•Tory Humphrey (tight end) should play after missing the last two games.
•Jemmy Jasmin (wide receiver) is questionable with a hand injury.
•Drew Mormino (offensive guard) is out indefinitely with a foot injury.
•Obed Cétoute (wide receiver) is out indefinitely with a hand injury.
Smith Rallies the Chippewas
After setting two school records in a 27-22 loss at Toledo, junior quarterback Kent Smith came up big at the end of CMU's 24-21 overtime victory over WMU.
The 6-5, 210-pounder ran for one TD and then combined with fellow Toledo Start High grad, Asante White, for the TD that forced the extra session.
In the UT game, Smith set school marks for 29 completions and the 446 yards in total offense. The 385 yards passing are third most.
Smith has rushed for seven touchdowns in the past six games and passed for seven more.
Smith's stats in his seven starts:
•Michigan State, 10-of-30 for 93 yards and nine rushes for 52 yards
•SEMO, 17-of-30 for 303 (two TDs) and seven for 29 (two)
•Kent State, 15-of-28 for 143 (one) and 10 for 38 (two)
•Bowling Green, 17-of-30 for 181 and eight for 23 (one)
•Northern Illinois, 12-of-21 for 115 (one) and nine for 50
•Toledo, 29-of-42 for 385 (two) and 15 for 61 (one)
•WMU, 21-of-39 for 205 (one) and 10 for 72 (one)
After lettering in 2002, Smith did not play last fall. He completed 10-of-32 passes that season for 96 yards and a TD and ran for 106 more and another score.
Smith's start at Michigan State was his first since the final game of the 2002 season when CMU lost a 35-10 home decision to WMU.
`Bam Bam' Under 100
For just the second time this season, Jerry "Bam Bam" Seymour was held below the 100-yard mark.
The 5-6, 190-pounder had 94 yards in 28 carries against WMU. He now has 13 100-yard games in 17 career games, six of them this fall.
Seymour, with career highs in yards (207) and rushes (36) in a win over Eastern Michigan in 2003, was named first team Freshman All-America by The Sporting News. He was a second team All-MAC pick.
Below are his 100-yard outings:
•New Hampshire 166 in 27
•E. Kentucky 116 in 25
•UCF 114 in 17
•EMU 207 in 36
•Akron 105 in 19
•WMU 162 in 27
•Navy 154 in 33
•Indiana 111 in 21
•Michigan State 164 in 26
•Kent State 131 in 28
•Bowling Green 155 in 28
•Northern Illinois 140 in 25
•Toledo 107 in 26
Seymour Can Catch, Too
Jerry Seymour is not only CMU's leading rusher but he's also its top receiver with 35 grabs for 298 yards.
He caught a career-high nine passes for 86 yards at Toledo and followed that up with seven more grabs for 34 yards against WMU.
Game at Ford Field Next for Chippewas
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