RB Mustafa Greene -- The Wolfpack hasn't had a 100-yard rusher all season. Could Greene be the first? He may get the chance, depending on whether Dean Haynes finds his snaps limited after last week's concussion. Keeping the Tigers defense honest by forcing it to guard against the run will be key for the success of the passing game as well.
LT Jake Vermiglio -- Vermiglio serves as a stand-in for the entire offensive line, which will have its hands full with Clemson's powerful defensive front. Vermiglio and his crew will have to watch out for him on every snap.
S Earl Wolff -- The redshirt sophomore is rapidly becoming the leader of the secondary, He led the team with team-leading 15 tackles against East Carolina and followed that with eight more against Florida State.
RB Jamie Harper -- Harper has played second fiddle to sophomore Andre Ellington all season, but he'll get his shot Saturday with Ellington on the sideline for at least two games with an injury. Harper is more of a pounder than a slasher and has been effective against N.C. State in the past, gaining 86 yards on just four carries last year against the Wolfpack, including a career-best 69-yard touchdown run.
QB Tajh Boyd -- Boyd, a redshirt freshman, has been told by Clemson's coaches that he'll see playing time this week what with starter Kyle Parker continuing to struggle. Coach Dabo Swinney declined to indicate to what extent and at what point in the game that might occur, but expect Clemson fans to be eager to get a glimpse of the young talent in action for just the fourth time this season.
PK Richard Jackson -- The senior, who lost his job to freshman Chandler Catanzaro in fall camp, will start again Saturday for the first time this season. Catanzaro missed field-goal attempts of 36 and 44 yards in the loss at Boston College, and coach Dabo Swinney is rewarding Jackson by reinstating the starter, who scored 101 points last season and was the only kicker in the nation to convert six field goals in a single game last year.
PLAYERS TO WATCH: State at Clemson
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