Freshman running back Marcus Lattimore has already gone over 1,000 yards this season. (Getty Images)
QB Stephen Garcia -- After being the butt of constant criticism from his coach, the redshirt junior has played so well that even Steve Spurrier has taken notice. He admits his quarterback has done everything that has been asked. If Clemson is able to establish consistent pressure with its front four, Garcia can't make poor decisions with the football if the Gamecocks are going to win on the road.
DE Cliff Matthews -- Although he struggled much of the season, the senior captain has come on strong since getting the medical clearance to remove a shoulder sling that stunted his performance. Probably no player wants to defeat Clemson more than this in-state performer. Can he get pressure against a Clemson offensive line that has been ultra-stingy in giving up sacks this season?
How Marcus Gilchrist handles 1-on-1 situations with Alshon Jeffrey and co. will be huge Saturday night. (Roy Philpott)
DE Da'Quan Bowers -- Bowers has plenty of incentive this week -- he's playing his arch-rival and he needs to just one sack to break Clemson's single-season record. "It would be a great achievement to break the sack record here, at Clemson, in a night game against our rival," Bowers said.
QB Kyle Parker -- If South Carolina has shown a weakness, it's in the secondary. Parker has been playing well recently, and if he musters a performance similar to last Saturday's, when he completed 15 of 17 passes for 194 yards and a touchdown, the Tigers stand a much better chance of knocking off the 18th-ranked Gamecocks.