The 27-yard pick-6 by Antonio Allen put a bitter end to Parker's career in Death Valley.
After going 7 of 17 with 117 yards and a touchdown, he was subbed out.
Tajh Boyd played the rest of the way and completed 10 of 18 throws for 73 yards.
"I think it was pretty decent. I did some good things. I feel like they recruited me for a reason. I went out there and made some plays. I got a little bit of a rhythm going," Boyd said.
Following the interception, Dabo Swinney figured it was time to make the switch, which came with just over 10 minutes left in the third quarter.
"I felt like [Boyd] needed the opportunity to go see what he could do," he said.
When asked about the substitution, Swinney said, "It was a decision that I felt like was best for our team, at that point."
After the game, Boyd said he didn't expect to play this week, after not taking a single snap with the first-team.
"I always want the best for Kyle. I wish he could have finished his last game here, but I think everything happens for a reason," Boyd said. "Hopefully, this will lead to some good things."
Offensive coordinator Billy Napier felt Boyd did well, considering the circumstances.
"He did some good things," Napier said. "I think we've got a lot to work to do. When they're open, he can make the throws. He did make some good decisions. It was evident he was doing what he was coached to do."
"For a freshman, I think he went out there and did as well as could have expected him to do."
Swinney liked how Boyd responded.
"That will be great, valuable experience for him as he gets ready to take the reins," Swinney said.
He declined to name a starting quarterback for the bowl game, but said it would "the player that gives us the best chance to win."
"Both of them will play—that's a pretty safe bet," Swinney said.
More time for Tajh Boyd?
CUTigers.com Top Stories
TIGERS WIN THRILLERClemson improved to 4-2 with a 60-58 win over Nebraska and helped the ACC win the 2016 ACC/Big Ten Challenge!
CUTigers.comYesterday at 7:13 AM
RECRUITING RADARIn our weekly Recruiting Radar, CUTigers Recruiting Analyst Gary McDaniel updates you on the latest news and intel on the Clemson recruiting front!
CUTigers.comMonday at 7:25 PM
TIGERS ADVANCE TO ELITE EIGHT!Austen Burnikel scored the first two goals for the Tigers, and Alex Happi added an insurance goal, his 4th in as many games.
CUTigers.comSunday at 7:34 PM
TIGERS #3 IN BOTH POLLSAfter a record blowout 56-7 win over arch-rival South Carolina, Clemson moved up to #3 in both of Sunday's polls and could potentially be #2 in Tuesday's College Football Playoff…
CUTigers.comSunday at 11:32 AM
PALMETTO PUMMELINGIn a historic 56-7 blowout of arch-rival South Carolina, #4 Clemson won the Palmetto Bowl for the third year in a row and improved to 11-1 headed into the ACC Championship Game!
CUTigers.comSunday at 7:47 AM