Assuming that Florida State jumps previously undefeated Stanford when the polls are released on Sunday, next weekend's game will be the fifth time a pair of ACC teams in the Top 5 have played.
And, by the way, GameDay is coming back to Clemson.
This is a big game, a "big dang" game, according to Dabo Swinney.
"It's one game. If we win it, it's not over. We've got a long way to go," Swinney said. "If you lose it, you're not out of it. You're still in a Top 10-like team, a BCS-like team and all those other opportunities are out there.
"Let's just face it: the winner of this game is probably going to win the division."
Vic Beasley is very well aware of the implications.
"There's going to be a lot of eyes on this game," he said. "It may be the biggest game in ACC history. I don't know. Our goal is to win the national championship.
"We're focused on Florida State now."
Finally, after more than a month of being two-score favorites, the Tigers have another test, another game that can't fall into the upset alert zone.
"I love it," Swinney said. "This is what you do it for, to be able to play in games like this [which] matter, nationally."
Handling Andre Williams"We wanted to physically out match them. Obviously, it starts up front, but our fit players, our safeties our corners. Setting the edge, our edge setters had to play well. And we had to hold point inside, out. They're a big, strong, physical line. We couldn't let him play behind his pads. He made a couple of runs there. He's a good player, but our guys brought hat time and time again, played with physical toughness. That was gang tackle, fit it right and set the edge." - Brent Venables
"They came in here with the nation's leading rusher…he averaged 2.9 yards per carry. They only had 94 yards rushing. That was a key emphasis for us, because we needed to improve our rush defense. We did a great job. That goes back to our front seven." - Swinney
Looking past B.C.?"A lot of people asked me that. The one good thing we've done this year is take it one game at a time. That wasn't an issue." - Adam Humphries
"Guys didn't have to look at but about two clips into Boston College video to realize this is a very well coached football team and they're going to come play hard. We're going to get the best of everybody. It doesn't matter who we play. Whoever we play, we're going to get their absolute best. I don't think these guys were looking ahead. I don't think the offense was looking ahead. I think that's an excuse. I just didn't think we executed very well up front." - Chad Morris
"I think coach Swinney does a great job of preaching that to us constantly. It's really engraved in our minds. Every game is a one-game championship. If we didn't win this game, next week doesn't matter. On the sideline, we just stay motivated. We've faced adversity before. It's always a good thing to face adversity like we did here, so we can watch film, correct it and learn from it." - Humphries
Morris on the run game issues"There's no question about that. We're very inconsistent right now in the run game."
"I think it's an issue all over. I just think we've got to do a better job of getting better. Can call better players, try to block better, got to run hard."
"We've got to be able to run the football around here. To get to where we want to be, we've got to be able to run the football."
"It's a point of emphasis. It's not frustration. It's a point of emphasis. We're going to run the football. That's what we do. That's who we are. That's to got to be our mentality."
Venables' perspective"It was a good performance. It was a really strong performance…I just love how we continue to respond just over and over and over, even when they made some plays. I've got a lot of admiration and respect for those guys, for all those things I'm talking about."
"Jayron [Kearse] had actually played, most of everything else, was playing good. It's a lot of snaps. It's a lot on a freshman. Those guys were throwing the kitchen sink at us."
"[Vic Beasley] played with great leverage, good gap control. Played in a very disciplined, tough manner right now. He's tough to handle on that edge when he knows it's pass time. He's playing good right now. All those guys are."
On FSU"We're going to have our hands full. They've got as good a collection as there is in college football. They've done an incredible job in recruiting. They're playing very well right now. They're talented on both sides of the ball and very well coached." - Venables
"I think we're all excited about it. I think the young guys and veterans are ready and prepared. I think we're going to have a great week of preparation. I'm excited to see how we play." - Humphries
"[Jameis Winston is] playing lights out. He's very special. Whatever it is, he's got it. He plays with great poise. He's a precision thrower. He can run. He's big, he's strong. In face of pressure, he makes great decisions, keeps his eyes down field when he's under duress. He's a very, very special player." - Venables
"I love playing against great quarterbacks. At the end of the day, you've got to go out there and out perform the guy that's out there on the field across from you, very excited to compete against [Winston]." - Tajh Boyd
More from the head coach"It's good to know that we can win a street fight. You have to give Boston College credit. They were a tough team, but we battled, we played very physically and we were just a little bit deeper than they were. It's good to pull out a win. The play of our defense was tremendous. We held the nation's leading rusher to 70 yard, and that was awesome. We've held opposing teams to 14 points in five straight games. Our defense is playing great.
"Our fans made a difference in the game. They gave us unbelievable energy when we needed it, especially in the third quarter. I can't thank our fans enough. They've turned this into a hard place for visiting teams to execute. Our defensive line took the game over."
"The standard here is really high. We had 500 yards of offense, but we're not happy. We left a lot on the field. You can't put the ball on the ground; that's what causes offenses like ours to stall and let teams hang around. We couldn't finish our drives on offense. We're not always perfect, but at the end of the day, it's all about the ‘W'."