The Wolfpack (19-12, 5-10 ACC) won the final two games of the series over the Tigers (20-11, 9-5 ACC).
Freshman Joe O'Donnell (1-0) entered the game in the third inning and allowed just two hits in 4.0 scoreless innings pitched to earn his first career win.
Patrick Peterson pitched the final 3.0 innings to record his first save of the year. Tiger starter Clate Schmidt (4-5) suffered the loss.The Wolfpack scored a run in the first inning and never relinquished the lead.
NC State added two unearned runs in the second inning thanks to a costly Tiger error and scored two insurance runs in the ninth inning.
Clemson concludes its six-game homestand Tuesday at 6:30 p.m. against Georgia at Doug Kingsmore Stadium on CSS and ESPN3.
Pack take series in Clemson
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