He is not eligible for a medical hardship because this was his fifth game of the year.
Lewis, a junior, was injured in the second quarter of Saturday's 13-3 loss to Georgia Tech.
He is the third Clemson player to be lost for the season. Reserve funning back Ray Ray McElrathbey was lost during the preseason with a torn ACL and reserve H-back Chad Diehl broke his leg against Furman.
Lewis Out for the Year
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