After Rambert's second touchdown with 3:07 remaining gave Clemson a 31-23 lead, Wake Forest had one last chance at a tying score.
But as Chris Barclay headed to the end zone, he was hit by Brian Mance at about the 5-yard line and lost control of the ball. It rolled through the end line for a touchback with 1:15 left and Clemson ran out the clock to stop a two-game losing streak.
Aaron Hunt's 34-yard field goal with 9:38 left put Clemson up 24-23 and the defense did the rest.
Quarterback James MacPherson had gone 159 passes this year without an interception for the surprising Demon Deacons (4-4, 2-3 Atlantic Coast Conference) before the Tigers (4-3, 2-2) rattled him into throwing three interceptions in the second half.
The Tigers had no answer for Wake Forest's powerful running game, which came into the game ranked 15th in the nation. The Deacons gained 364 yards rushing, their most since 355 yards against William & Mary in 1956.
When Tarence Williams scored on an 11-yard to put Wake ahead 23-14 with 13:17 to go, things didn't look good for the orange-clad crowd of 81,000 at Death Valley.
That's when Clemson's defense took control.
Wake scored on five of its first seven possessions, then not at all after Williams' TD.
MacPherson's first interception stopped one third-quarter drive. Then Travis Pugh recovered a fumble by Cornelius Birgs on the next possession.
Rambert closed it to 23-21 with a 2-yard score. MacPherson threw his second pick on the next drive.
Following Hunt's go-ahead field goal, Wake Forest drove to Clemson's 49 when MacPherson, under pressure, was intercepted by Altroy Bodrick.
Hunt appeared ready to add a field goal when Clemson's offense stalled at Wake's 12, but holder Jeff Scott dove ahead on the fake for a first down. Rambert finished things off with a second scoring run.
Wake Forest outgained Clemson 522-280 but lost for the 23rd time in its last 26 contests against the Tigers.
MacPherson finished 10-of-18 for 158 yards. Williams had 97 yards rushing and Barclay had 89.
Wake Forest used three Matt Wisnosky field goals to take a 16-14 lead at the half.
Tigers Rally Past Wake Forest
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