After all, this will be the last opportunity for the Lake Butler, Fla. native to play in front of many of his friends and family against his favorite team growing up - the Florida State Seminoles.
"This past week it's been crazy," he told CUTigers.com. "I told my mom to handle all of the tickets because I'm just trying to stay focused on the game and make sure I take care of my business.
"I should have a lot of family and some friends there watching me - so yeah I want to out there and make some plays like I've been doing the last couple of weeks."
Spiller has gotten off to a strong start in his junior season and was truly the reason Clemson was able to put enough points on the board last weekend in a 27-21 win at Boston College.
He finished with eight carries for 62 yards, six receptions for 105 yards and also returned a kickoff 64 yards in the fourth quarter just after Boston College rallied to take its first lead of the game.
But this week, he's facing a different sort of challenge with the Florida State defense. Unlike the big physical style of Boston College, FSU is smaller and much faster.
In addition, the environment at Doak-Campbell Stadium poses much more of a problem.
"It's a great environment down there at their place. This is one of the top five defenses in the nation and it's a big test for offense," he said. "If our defense can keep doing what they are doing we know we are going to be in the game for four quarters, we just need to execute at a higher level on offense and we'll be fine."
Spiller is also still keeping an eye on his hamstring, which caused him to miss the Georgia Tech game in mid-October.
"My main thing against Boston College was seeing how my hamstring would handle for four quarters and it did pretty good. I was a little winded so I worked on that this week.
"But I'm right at 100 percent right now. I still had a lot of treatments this week to make sure I could be full speed against this defense. You can't be half speed against these guys. The trainers really did a great job."
And now that's back close to full strength, his focus Saturday is on beating the Seminoles, and getting this team back into contention in the ACC.
"It's going to be a great game and it's going to feel good to be back playing in front of the home folks," he said. "But we've got to win. We want to close this season strong and show everybody just how could we can be and that starts Saturday against Florida State."
Spiller Back to 100 Percent?
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