Butler was selected in the fifth round by the Pittsburgh Steelers with the 33rd pick.
During his senior season, he had one interception, finishing with 11 for his career.
Butler finished his career tied for second in school history in interception return yards with 243 and he had 13 career takeaways.
"He is an experienced, productive cornerback who has upside, but isn't a physical defender," Scout.com NFL Draft expert Chris Steuber said. "He has a nice frame, but lacks bulk. He transitions well with receivers and has good instincts and awareness in coverage.
"He has great ball skills and playmaking ability, but has a tendency to lose focus and give up a big play," Steuber said.
Clemson ranked in the top 20 in the nation in pass defense all four years Butler played in the Clemson secondary.
Butler is one of four Clemson players selected so far in this year's draft.
C.J. Spiller (Buffalo - first round), Jacoby Ford (Oakland - fourth round) and Ricky Sapp (Philadelphia - fifth round) have also been drafted already.
Steelers add Butler in fifth round
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