The 2010 matchup also provides Clemson one more warm up before travelling to Auburn for what could be a nationally televised game between two nationally ranked teams.
Simply put, it's going to take an overlook of epic proportions the Tigers to slide into the week three meeting on The Plains with a loss the Blue Hose.
Perhaps PC head coach Harold Nicols said it best when the 2010 schedule was released earlier this year. In addition to facing Clemson in week two, the Blue Hose will battle Wake Forest in week one.
"This season we will play the most challenging schedule in PC football history," Nichols said. "The first two games will be very exciting for our fans and alumni - and we are excited about the opportunity."
Returning to PC from last season is starting quarterback, Brandon Miley; the top two rushers, Lance Byrd and Trandon Dendy and receptions leader Patrick McKoy.
On the defensive side of the ball, the Blue Hose welcome back last season's leading tackler, Justin Bethel; top sack-man, Derren Evans, and interceptions leader Damon Lawrence.
Regardless of the returning production, the Blue Hose finished 0-11 in 2009. PC scored more than 21 points only twice, both of which coming to Big South Conference opponents.
Harold Nichols, a 1989 alumnus of PC, came from Bucknell University, where he was the offensive coordinator and assistant coach since January 2008. (PC Athletics)
"The 2010 schedule is the most challenging in PC's football history. Our team is prepared for the challenge it will face," said coach Harold Nichols. "We are looking forward to playing in those arenas and for laying the foundation for where this program is headed. It is a journey that we are going to be on."
For those Tajh Boyd fans clamoring for the highly touted quarterback to get work under center in 2010, this will be the game to watch.
He's likely get the lion's share of the snaps with points coming early and often for Clemson. How much Kyle Parker plays depends on how comfortable the Clemson staff is with letting their starter risk injury before Auburn and the ACC schedule.
Same goes for the Tigers' running back tandem of Andre Ellington and Jamie Harper and Dwayne Allen. Roderick McDowell gets his shot to work in a feature role through most of the game while the freshmen tight ends and unproven wide receivers will have most of the targeted opportunities for receptions.
Expect plenty of sacks and turnovers while the Clemson defense is on the field. Even if the offense sputters, DeAndre McDaniel and the rest of his mates on the Tigers' defense are a threat to score out-score PC.
HALE'S WAY TOO EARLY PREDICTION: Clemson 56 Presbyterian 0