The Buffs dropped to 14-6 overall and 3-2 in the conference with a sold out home game slated for Tuesday night against No. 2 Kansas.
Media and fans who are eager to have a winning college basketball team in Boulder to follow probably got a bit ahead of themselves over the past two weeks talking about NCAA Tournament possibilities and maybe even finishing in the top half of the Big 12.
Today's setback was the 24th consecutive defeat for Colorado in Norman, Okla.
Senior Cory Higgins led the Buffs with 15 points, but CU played from behind most of the afternoon. Higgins set a new school record for career minutes played, passing former Buff Jay Humphries to move into the top spot with 3,877 career minutes logged.
Higgins also became just the sixth CU player in history to score more than 1,700 points in a career. He has 1,713 to his credit.
The Buffs tied the game at 52 with less than 4 minutes remaining, but couldn't get stops on the defensive end and come up with baskets offensively in crunch time. Oklahoma won the game at the free throw line making 13 of its final 16 attempts.
Five Oklahoma players scored in double figures, led by Cade Davis, who also had 15.