Senior guard Katie Fagan had 14 points to lead a dismal scoring effort for the Buffs (3-1), who scored just 16 points in the first half of their first loss of the year.
Minnesota's 43-16 lead at halftime following CU's shooting just 6-20 in the game's opening 20 minutes represents the third-largest halftime deficit in CU history, and the single most daunting since the Buffs trailed by 26 to Stanford late in the 2000 season.
Minnesota, 93-41 victors of Southern University in the first round of the Classic Saturday night, improves to 2-0 on the young season and leads the nation in field goal percentage (51.3%). The Lady Gophers shot better than 57% from the field against the Buffs.
Colorado returns home to host the 17th Annual Coors Classic this Friday. California, Lehigh, and Idaho State are entered in the round-robin style weekends, with CU opening play against Idaho State Friday night.