The loss dropped the Buffs to 11-19 overall and 3-13 in the Big 12. CU's three conference wins matches its win total from last year's squad.
The Buffs are now the No. 12 seed in the conference post-season tourney, which takes place Thursday through Sunday in Kansas City.
The Buffs will face No. 5 seed Baylor in the first round. Tipoff is scheduled for 1 p.m. (MT), and the game will be broadcast on one of the ESPN family of networks.
Baylor defeated Colorado in Boulder on Feb. 27, 68-57.