Anna Martin hit five 3-pointers and made seven of her 11 field goal attempts for the Blue Demons (4-1). Megan Rogowski scored 17 points, Kelsey Reynolds 11 and Katherine Harry added 10 points with 12 rebounds.
The Rainbow Wahine held an early lead at 11-9, but DePaul used a 19-6 run to take a commanding lead, which it never relinquished. Hawaii cut the Blue Demons' lead to 52-44 on Kanisha Bello's 3-pointer with 14:26 left, but could get no closer.
Kamilah Jackson had 19 points and 12 rebounds to lead Hawaii (1-3), which also got 16 points from Breanna Arbuckle.
DePaul led 42-30 at halftime.
Martin leads No. 18 DePaul past Hawaii
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