Missed free throws down the stretch cost the Demons in this one as DePaul (4-2) missed four shots from the charity stripe in the final 30 seconds.
Murphy Holloway scored the game winning layup following a steal for Mississippi (6-1) with 3.7 seconds left in the game.
"It was a tough loss for us given the fact that we made a valiant comeback in the second half," said DePaul coach Oliver Purnell. "Our guys did a great job of battling back to the point where we had a lead and we're on the free throw line to salt away the game and didn't convert. That was a huge factor in us not getting away with the win."
The Blue Demons were forced to go to a smaller lineup when senior center Krys Faber fouled out, with 4:24 remaining in the game, and freshman Dorrell Robertson was on the bench with four fouls. That kept DePaul at a size disadvantage in the final minutes.
"At that point, free throw block outs become an adventure," said Purnell. "Every time a shot goes up you're concerned about getting a defensive rebound and in particular a free throw."
Four players finished in double-figures for Ole Miss. Nick Williams scored 17 points. Holloway added 16 and freshman Jarvis Summer contributed 12 points. Dundrecous Nelson chipped in with 10 points off the bench.
DePaul will go as far as their young sophomores can take them this season. Brandon Young led all scorers with 18 points and Cleveland Melvin recorded a double-double of 14 points and 10 rebounds.
The Blue Demons return to Allstate Arena on Monday night to face Milwaukee.
- Former Blue Demon David Booth was in attendance at tonight's game.
- Donnavan Kirk sat out the game with soreness in his back and is day-to-day.
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