DePaul (10-8, 1-5) pulled to within two with 14:02 left in the game on an 8-0 fueled by Moses Morgan's three pointer.
But, the Blue Demons couldn't turn the corner. Rebounding and shot selection cost DePaul in this one.
The Blue Demons were outmuscled on the glass by a 47-25 margin.
"A couple of areas I thought we struggled in that didn't give us a chance to really win the ballgame," said DePaul coach Oliver Purnell. "One of them is obviously rebounding. Then I thought we turned the ball over too many times. Shot selection could have been better. When we took bad shots those were like turnovers. We're just not playing well enough for long enough. It's that simple."
Georgetown (15-3, 5-2) was led by the shooting of Jason Clark. Clark scored a career-high 31 points while shooting 11 of 14 from the field.
"He made some really tough shots," said Purnell.
"It was a difficult game for him in that he had to deal with their press and their pressure most of the time, but then also he was clearly in a groove and the ball was going in," Georgetown coach John Thompson III said of Clark. "I thought obviously Jason played very, very well."
Henry Sims scored 16 points for the Hoyas before fouling out with three minutes to go. Hollis Thompson contributed with 14 points.
DePaul was led by sophomore forward Cleveland Melvin who scored 19 points. Brandon Young chipped in with 16 points.
Moses Morgan came in off the bench to pour in 17 points including making five of eight from beyond the arc.
"I just wanted to come out aggressive," said Morgan. "The last few games I haven't been shooting really well. So I just wanted to shoot the ball and come out aggressive."
It was the first career start for junior point guard Worrel Clahar, who finished with seven points, five assists, and four steals.
"He's been playing good," Purnell said of Clahar earning the start. "We needed some more energy and athleticism."
"It was something I worked real hard for," said Clahar. "I try to get shots up late night in the gym, hit the books, and work hard on my game tremendously every night."
The Blue Demons next host South Florida at 1 p.m. on Sunday at Allstate Arena.
DePaul Falls to No. 10 Georgetown 83-75
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