DePaul's Charles McKinney cut to the back door and drove to the basket to tie the game up 79-79 for the Blue Demons at the end of regulation.
But, untimely turnovers proved costly for DePaul (11-15, 2-12) in the overtime period. In total, Louisville (21-6, 9-5) scored 30 points off of Blue Demon turnovers.
"The good is that we played at a much higher level than we've been playing," said DePaul coach Oliver Purnell. "We put ourselves in a position to win. If we play our style of basketball, and are aggressive, and take that on to the next game and down the stretch, we're going to win some games."
DePaul sophomore point guard Brandon Young had struggled of late, but bounced back today with a season-high 27 points, five assists, and four steals. Young felt like he had something to prove.
"I had something to prove," said Young. "I keep hearing people talk. We came up short, but I had a chip on my shoulder. I just keep working harder. I'm a team player. I just want to win games for my team."
"Brandon played much better than he's been playing," said Purnell. "He's so aggressive. In our style he has to be that way. It raises our level of play when he is that way."
One area of the game where DePaul dominated today was in the paint. The Demons outscored the Cardinals in the paint by a 48-29 margin.
Sophomore transfer Donnavan Kirk started for the second straight game in the post and finished with 11 points including a three point shot.
"I thought he played well today," said Purnell. "I thought he was a real presence. He played 34 minutes. That's big for us."
Cleveland Melvin recorded his fourth double-double of the season with 14 points and 10 rebounds.
Kyle Kuric led the way for the Cardinals with 25 points. Chris Smith chipped in with 20 and Russell Smith (no relation) added 16 points and stole the ball six times.
Louisville coach Rick Pitino walked away from Allstate Arena with respect for the Blue Demons.
"They play their asses off every night and they don't come away with much at times, but that's the building process you've got to go through," Pitino said of the Blue Demons who started two freshman and three sophomores today.
DePaul has a tight turnaround and must now travel to New York where they face the St. John's Red Storm in a rematch on Monday night.
DePaul Falls in Overtime to No.19 Louisville
We Are DePaul Top Stories
On Campus: Weekend of September 24thA number of the nation's top prospects will take official and unofficial visits this weekend. Who is headed where? Scout breaks down the key visits of the weekend.
Scout HoopsFriday at 5:07 AM
DePaul Learns Big East ScheduleCHICAGO – The Big East conference unveiled the 2016-17 conference schedule today as well as TV assignments for FOX and CBS coverage with the Blue Demons opening on the road at…
We Are DePaul09/13/2016
Hoops Recruiting Inside ScoopWhat's the latest on the top recruits in the country? Scout's basketball recruiting team -- Evan Daniels, Brian Snow and Josh Gershon -- break down the latest.
Updated 2018 Top 100The 2018 player rankings have been extended from a top 75 to a top 100. Marvin Bagley, a 6-foot-10 power forward, held on to the No. 1 spot, while Zion Williamson and Romeo…