The Fighting Irish (15-4, 3-2 BIG EAST) had a chance to win in the closing seconds, but Holly Medley stole the ball from Charel Allen with two seconds left and dribbled away as the clock ran out.
DePaul (14-4, 3-2 BIG EAST) shot 72 percent in the first half and beat the Irish for the third straight time.
The Blue Demons, which led by two at halftime, went on a 9-0 run early in the second half to open a 58-49 lead. Allie Quigley ignited the run when she converted on a three-point play, then Naughton did it again 36 seconds later. Missy Mitidiero capped the run with a 3-pointer.
The Irish cut the lead to 71-70 when Allen hit a 3 with 4:37 left. But the Blue Demons stretched the lead to five moments later when Natasha Williams scored inside and Quigley made a pair of free throws.
Brittany Mallory's two foul shots for the Irish cut the lead to 81-80. Quigley caught the inbounds pass and while being covered by Mallory lost her dribble out of bounds to give the Irish a chance with 4 seconds left.
Quigley scored 16 points for DePaul, Williams had 14 and Mitidiero added 12.
Ashley Barlow scored a career-high 23 points for the Irish, Allen had 17 points on 5-of-14 shooting and Erica Williamson tied her career high with 16 points.
Game Notes: DePaul is 2-2 this season against ranked teams... the Blue Demons have won six of seven road games... in the last seven-plus seasons (238 games), DePaul is 83-5 (.943) when scoring at least 80 points... Deirdre Naughton tallied her ninth career game (fourth at DePaul) of at least 20 points... it was also her 40th career game (16th at DePaul) in double-figures... Allie Quigley is 19-for-19 from the free throw line in the last two games against Notre Dame... she extended her BIG EAST-best streak to 28 straight games in double-figures... in the last nine games, Quigley is 46-for-50 (.920) from the free throw line... the Blue Demons have won three straight over Notre Dame and lead the series, 18-11... the win was the first at the Joyce Center since a 62-49 victory on Feb. 11, 1992.
DePaul Tops No. 16 Notre Dame
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