Koshwal's basket with 2:53 left put the Blue Demons up for good, 52-51.
Jabari Currie added 12 points for DePaul (7-4), which went 8-for-8 from the free throw line over the final 1:27. Dar Tucker had 11 points – all in the second half - and six rebounds for the Blue Demons, while Will Walker had 10 points.
Kevin Lisch led Saint Louis (6-5) with 19 points and freshman guard Kwamain Mitchell tied his career high with 16 points and had five rebounds and five assists.
The Blue Demons' largest lead was 31-22 with 4:17 left in the first half and they led 33-27 at halftime. Saint Louis took its first lead at 44-43 with 8:22 left in the contest.
Jabari Currie played his 100th game in a Blue Demon uniform.
Mac Koshwal recorded the eighth double-double of his career and the third of the season.
Mario Stula scored his first collegiate points with a three-point field goal in the first half.
Devin Hill now has 10 blocked shots in his last three games and 26 for the season (last season Mac Koshwal led DePaul with 24 the entire season).
DePaul shot a season-best .720 (18-25) from the free throw line.
The victory was DePaul's first of the season when trailing with five minutes to play, the Blue Demons had been 0-3 prior to this evening.
The Blue Demons are now 6-2 when holding opponents under 70 points.
DePaul leads the series 34-27 and has won three straight.
DePaul will play the winner of the Creighton/Fresno State game for the championship of the Las Vegas Classic. Game time is 9:30 p.m. (CST) and the game will be broadcast on WSCR (670 AM) in Chicago. The contest will also be streamed on the internet at www.B2tv.com.
DePaul Stops Saint Louis at Las Vegas Classic
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