Woodfox, who was selected the tournament MVP, went 5-of-9 from 3-point range for the Bluejays (10-2), who have won seven straight.
Sophomore forward Dar Tucker led DePaul (7-5) with a career-high 32 points. Tucker was 12-of-22 from the field and grabbed six rebounds. Sophomore center Mac Koshwal had 13 points and a career-high 22 rebounds for the Blue Demons.
Koshwal was named to the All-Tournament team and was joined by teammate Jabari Currie, who scored 10 points. Will Walker added 12 for the Blue Demons.
After the Bluejays led 62-48 with 11:21 left, the Blue Demons cut the lead to 75-73 with 2:20 remaining. But Woodfox's basket with 1:01 to go and his two free throws with 29 seconds remaining gave Creighton a six-point lead.
Creighton was 18-of-19 from the free throw line, while DePaul was 13-of-24.
DePaul outrebounded Creighton 42-28 but had 18 turnovers.
Dar Tucker became the 27th player in school history to score 32 or more points in a game and he is now tied for the 50th-best single game offensive performance in DePaul history.
Tucker became the first Blue Demon to score 30 or more points since Draelon Burns tossed in 31 against West Virginia on February 27, 2008.
Mac Koshwal's 22 rebounds was tied for the fifth-best single game effort in DePaul history and he is one of five Blue Demons to grab 22 or more caroms in a game.
The last time a DePaul player had 20 or more rebounds in a game was when Andre Brown grabbed 27 boards at TCU on February 6, 2002.
DePaul finished second in a regular season tournament for the first time since the 2003 Michigan State Invitational.
DePaul plays its final non-conference game of the 2008-09 season when Alcorn State comes to the Allstate Arena for a 1 p.m. (CST) game.
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DePaul vs. Northwestern PreviewThe Blue Demons travel to nearby Evanston on Saturday night for their first road game of the season. We preview the game vs. Northwestern in this report.
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