DePaul (8-17, 0-12) coach Jerry Wainwright credited Seton Hall (14-9, 5-6) point guard Eugene Harvey for controlling the game for the Pirates.
"He runs his team," Wainwright said. "They dance to his beat. He's everything you want in a point guard."
Harvey scored 19 points and dished out six assists.
Three others finished in double-figures for Seton Hall. Robert Mitchell scored 16 and grabbed nine boards. Freshman guard Jordan Theodore contributed 11. The Demons did manage to hold Seton Hall's leading scorer Jeremy Hazell to 13 points on five of 14 shooting.
The Pirates scored 17 points off of 13 Blue Demon turnovers as DePaul's ballhandlers wilted under the Seton Hall pressure.
"We wanted to get the game into the 70's and jump on them early," said Seton Hall coach Bobby Gonzalez.
DePaul was led by sophomore Dar Tucker with 19 points, yet only one other Demon finished in double-figures as the team struggled offensively shooting 32.7% from the field. Sophomore Mac Koshwal finished with a double-double of 11 points and 16 rebounds. Junior guard Will Walker was held to an uncharacteristic eight points.
DePaul dropped to 0-12 in the Big East. Things don't get much better as their next three opponents are all ranked in the top 15. With spring-like temperatures in Chicago today, Wainwright's seat in Lincoln Park has been getting awfully warm.
"I've never been in this situation," Wainwright said.
Neither has DePaul which is just one loss away from tying the school's longest losing streak.
Tonight was Seton Hall's first win at Allstate Arena.
Pirates Sink Demons 72-49
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