DePaul (8-20, 0-15) just cannot catch a break as they lost their 15th straight game.
The Demons scratched and clawed their way down the stretch after the Wildcats led by as much as 12 with 6:21 to go in the game.
Villanova could do little wrong as they shot a blistering 61.5% from the field in the second half to escape with the victory.
"We got lucky," said Villanova coach Jay Wright. "They outplayed us."
Scottie Reynolds helped preserve the win for the Wildcats by scoring on a layup and a jumpshot while going a perfect four for four from the free throw line in the final three minutes.
"Scottie made two incredible plays or we're not even talking about this," Wright said.
Villanova (23-5, 11-4) finished with four players in double-figures. Dante Cunningham and Reynolds led the way with 18 apiece. Coming off the bench, Corey Fisher scored 12 and Corey Stokes chipped in with 10.
Junior guard Will Walker led all scorers with 23 points on seven of 16 shooting while dropping in six three-pointers.
Sophomore Dar Tucker contributed with 16 points and five assists, but shot one from 11 from behind the arc.
Sophomore forward Mac Koshwal finished with a double-double of 17 points and 13 rebounds.
The Blue Demons close out their home schedule on Saturday morning with a matchup against the St. John's Redmen. "Our challenge is – can we start Saturday's game with the way we finished this one," stressed DePaul coach Jerry Wainwright.
#10 Villanova Narrowly Defeats DePaul
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