Sindarius Thornwell scored 24 points, Duane Notice added 17, as South Carolina rallied from 10 points down for a second straight NCAA victory.
Grayson Allen led Duke with 20 points.
Mike Krzyzewski said the Gamecocks wore his team down and called them
" The most physical team we faced all year"
The Blue Devils finish the year 28-9 and will look forward to next season and a team that will look a lot different.