Shelden Williams scored 16 points to lead four Blue Devils in double figures and No. 6 Duke forced a slew of turnovers in a 72-50 victory over No. 5 Michigan State on Wednesday night.
Duke (4-1) took control of the game in the first half with a 20-2 run during which the Spartans committed 17 of their 20 turnovers.
The Blue Devils handed Michigan State (3-2) its most-lopsided loss at the Breslin Center since a 25-point setback against Minnesota in 1997, and just its fifth loss at home since the start of the 1998-99 season.
Duke's J.J. Redick scored 13 points, Shavlik Randolph had 11 and Chris Duhon added 10 points and six assists.
Michigan State didn't have a player score in double figures. Chris Hill and Kelvin Torbert each scored eight.
When Duke didn't harass the Spartans into a turnover, it made it tough for them to make shots. The same was not true when the Blue Devils shot.
Duke shot 59.2 percent and limited Michigan State to 40 percent.
The Spartans have only begun one of the toughest schedules in college basketball history. Michigan State, which lost to top-ranked Kansas last week, will play Oklahoma, Kentucky, Syracuse and UCLA before the Big Ten season starts.
The Spartans, who lack a true point guard, had 24 turnovers against Kansas.
Paul Davis and Alan Anderson, two of Michigan State's top players, were benched for most of the second half. Davis had seven points and Anderson had four points and five turnovers.
At one point, Michigan State coach Tom Izzo sat between the two standouts toward the end of the bench.
Izzo is 0-3 against the Blue Devils.
Duke's defense led to Michigan State's horrific start.
The Spartans missed their first six shots and had six turnovers less than five minutes into the game. But despite having as many turnovers (10) as points, it led midway through the first half.
Moments later, Duke took over.
Their decisive run gave the Blue Devils a 33-15 lead with four minutes left, and they led 38-24 at halftime.
Duke scored the first six points of the second half to earn a 20-point cushion that it didn't have any trouble maintaining.
The Blue Devils improved to 5-0 in the ACC-Big Ten Challenge, and the Spartans fell to 3-1.
Michigan State wore silver uniforms, with green and white trim, because of the season-long 25th anniversary celebration of the national championship Magic Johnson led the Spartans to in 1979.