Justin Gray scored 18 points for the Demon Deacons (12-2, 2-1), who have lost seven straight meetings here. Eric Williams, who came in leading the team with 16 points a game, finished with just six points.
Duke has dominated Wake Forest here in recent years, winning its last six meetings by an average of 24 points a game. The Demon Deacons haven't won at Cameron Indoor Stadium since Tim Duncan led them to an 81-69 victory in January 1997.
Duke had about 36 hours rest after beating North Carolina State 76-57 on Thursday night, but showed no signs of fatigue.
Williams led a defensive effort that locked down an offense ranking third nationally at 87.7 points. When the Demon Deacons managed to get past the perimeter pressure, Williams and the Blue Devils closed the door by blocking 12 shots and altering countless more.
Wake Forest shot 35 percent for the game.
Duke shot 52 percent, including a 10-for-19 effort from 3-point range.
The Blue Devils used a 14-2 run in the game's opening minutes to take a double-digit lead they would maintain for most of the way. Wake Forest hung around and closed the gap to three points midway through the second half, but never could dig out of its early hole.
After Gray's 3-pointer pulled Wake Forest to 45-42 with 15:53 to play, the Blue Devils responded with a 10-2 run, which included 3s by Redick and Ewing. Redick's long jumper from the left wing gave Duke a 55-44 lead with 13:27 to play.
Wake Forest got no closer than eight points the rest of the way.
Eric Williams got the Demon Deacons off to a good start with the game's first basket, but Duke answered with a 14-2 spurt. Five Blue Devils scored during the run, which featured a 3-pointer from Ewing and an alley-oop layup from Ewing to Duhon.
The only blemish for Duke during the spurt was when Redick missing his first free throw of the game, snapping his ACC-record streak of 54 straight dating back to last season.
Duke led 41-30 at halftime.